This was an excellent talk by John Gruber at Çingleton about the next 5 years in computing.
His closing line is amazing advice:
The only thing any of us are going to regret is if we don’t aim big enough. If you don’t feel you are now in a position to do the best work of your entire career, to look back and say ‘I was there’ ‘I did this’ ‘I made this thing a reality,’ then we you need to find a new position. This chance will never come again.
We are so lucky that [this opportunity] even came this once.”